Rome-Fiumicino International (FCO) is Italy's largest, but the Naples International Airport (NAP) is closer to the Amalfi Coast.
Airlines
Alitalia, American, Continental, Delta, and United all fly direct from major U.S. cities to Rome (a three-hour drive to the Amalfi Coast). Eurofly flies direct into Naples, which is only about an hour and change to the Amalfi Coast.
Flight Times
8 hours to Rome from New York; 12.5 hours to Rome from Los Angeles. Given all the major carriers, you're sure to find a time to leave of your choosing, but it's best to take the red-eye and arrive in the morning – you'll still be hours away from your hotel room.
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