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For the most part, the Amazon is not a very friendly destination for people with mobility problems. But several companies offer cruises with all the frills that include the Amazon River and, in some cases, the Negro and/or Solimões Rivers in their itineraries. Many excellent boat tours-cum-nature trips … more leave from Manaus and include wildlife spotting, bird watching, and visits to local communities (though generally not to Indian reservations which require special permission from FUNAI, the federal agency for indigenous affairs).