Most people fly into Miami (MIA) or Fort Lauderdale (FLL) and then either drive, ferry, or catch a connecting flight to Key West. Direct flights to Key West (EYW) are rare and more expensive.
Airlines
US Airways, Continental, Delta, America Airlines, Alaska Airlines, and America West are just a few of the major carriers that fly into Miami International Airport. EYW receives flights from many major airlines, most of which connect through Miami.
Flight Times
Two hours to Miami from the Northeast; 3.5 hours from the Midwest; 5 hours from the West Coast, and 7 hours from the Northwest.