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De Santos Gyrate to house and techno music courtesy of a state-of-the-art sound system or head to the rooftop terrace to relax with cocktails on oversized beds. The party starts pumping around 1am. El Centro; Calle Morelos 771; 011-52-322-223-3052; www.desantos.com.mx
J and B Salsa Club Kick up your heels to some serious salsa at this Latin dance club, a local hot spot with a live band on Fridays and Saturdays. Ave. Francisco Medina Ascencio, km 2.5; 011-52-322-224-4616
Kit Kat Club A swanky spot where the hip come to lounge on plush, animal-print settees and sip martinis while listening to groovy beats. Los Muertos Beach; Pulpito 120; 011-52-322-223-0093
La Bodeguita del Medio Find authentic Cuban flair here on the malecón – cigar aficionados can purchase Cubans at the bar's tiny shop and then survey the bay while relaxing in the upstairs room. Downtown; Paseo Diaz Ordaz at Allende; 011-52-322-223-1585
La Palapa Restaurant and Lounge Nestled right on Los Muertos Beach, this is a great spot to wind down a day on the sand with a sunset snack and a cerveza. Los Muertos Beach; Pulpito 103; 011-52-322-222-5225; www.lapalapapv.com
Nikki Beach Restaurant and Bar The scene calls to mind Miami: patrons lounge on beachfront beds while sipping sexy libations and noshing on tasty treats like Mexican shrimp sushi rolls. Marina Vallarta; Paseo De La Marina Sur, 205; 011-52-322-226-1150