On April 8, 2021, board Regent Seven Seas Cruises' luxe new Seven Seas Splendor in Barcelona. From there, you'll cruise the Strait of Gibraltar and enjoy three ports of call in the Canary Islands. This 10-night itinerary includes all meals, beverages, and shore excursions — plus round-trip, business class air to Spain. Learn more. 

Be among the first guests to sail to Antarctica with Norwegian Cruise Line. This 12-night journey embarks from Buenos Aires in January 2021 and even includes a stop at Deception Island. The island, which is located at the tip of the Antarctic Peninsula, is home to one of the largest penguin colonies on the planet. Learn more. 

Read more: 7 Things to Know Before Booking an Antarctica Cruise

Bypass the major commercial ports of the Caribbean in favor of gems like Virgin Gorda and Montserrat. This idyllic six-night voyage from Windstar Cruises sails round-trip from San Juan on several dates between January and March 2021. Learn more.

Read more: 7 Under-the-Radar Caribbean Islands

Oceania Cruises' 9-night Idyllic Greek Isles itinerary combines historic destinations (think Istanbul and Rhodes) with some of the Aegean's best beach destinations. It's also worth noting that this is one of the few itineraries on the market that calls on both Crete and Cyprus. Begin your odyssey on July 30, 2021. Learn more.

Read more: 6 Ways to Cruise the Greek Islands for Less

Visit all three ABC Islands — Aruba, Bonaire, and Curaçao — on this seven-night cruise aboard Norwegian Jewel, which also stops in Costa Rica and Panama. While most other voyages to the ABCs take two weeks or longer, this one from NCL will cut the time in half beginning November 2021, when the ship moves to its new homeport in Panama City. Learn more.

Pair traditional Mexican Riviera ports (think Cabo and Puerto Vallarta) with under-the-radar destinations like Mazatlan on this nine-night voyage, which sails round-trip from San Diego on April 9, 2021, aboard Holland America's MS Maasdam. Learn more.

Read more: 10 Free and Affordable Things to Do in Mazatlán

Oceania Cruises' 11-night Viking Homelands itinerary allows passengers to explore remote ports in the Faroe Islands, northern Iceland, Norway, and the Shetland Islands. Set sail on August 13, 2021. Learn more.

Read more: 10 Icelandic Natural Wonders You Can See for Free

Carnival Cruise Line offers one of the few Hawaii itineraries on the market that sails round-trip from the mainland US. Travel to Oahu, Maui, Kauai, and the Big Island on February 20; April 5; October 16; or November 27, 2021. Learn more.

Read more: How to See Hawaii (and Save) With a Cruise

Norway-based Hurtigruten, which specializes in Arctic expedition cruises, offers an 11-night circumnavigation of Norway's Svalbard archipelago, where you can admire majestic glaciers, spot polar bears, and bask in the midnight sun. The itinerary departs on several dates throughout June 2021. Learn more.

Journey through the less-frequented ports of the lower Danube River, including the Iron Gates and Belgrade, on this eight-night itinerary from Avalon Waterways. Cruise on select dates between April and September, 2021. Learn more.

Read more: 7 Reasons to Take a Lower Danube River Cruise

Thanks to Windstar's intimate small-ship fleet, this 10-night voyage aboard the 312-passenger Star Breeze features several off-the-beaten-path ports (including Prince William Sound) that tend to be inaccessible to larger ships. Set sail July 5 or August 10, 2021. Learn more.

Read more: 5 Reasons Why Cruising Is a Great Way to Experience Alaska

If you love Italy, then you'll say grazie to Regent Seven Seas Cruises for crafting this 12-night Mediterranean voyage, which sails from Barcelona to Venice in May 2021. Along the way, you'll visit  Monaco, Greece, Montenegro, and Croatia, along with five Italian ports. This luxe, all-inclusive voyage also covers round-trip, business class air to Europe. Learn more.

Cross the Indian Ocean from Singapore to the Maldives aboard the luxe, all-inclusive Crystal Symphony. Enjoy ample beach time in Phuket and book multiple excursions in Sri Lanka. (The itinerary includes two days at both destinations.) Set sail in February 2021. Learn more.

Virgin Voyages' new Scarlet Lady is set to debut in Miami later this year. In 2021, embark on a long-weekend sailing to the line's new private beach club in Bimini before stopping in Key West. There are plenty of departure dates to choose from throughout the year. Learn more.

Read more: 8 Things to Know About the New Virgin Voyages

Board Silversea Cruises' all-inclusive Silver Moon in Cape Town; then, visit five countries along the continent's west coast. Highlights include Walvis Bay, Namibia, and Banjul, the charming seaport capital of Gambia. The adventure begins on April 24, 2021. Learn more.

Kick-off summer 2021 with a cruise around Ireland, which departs June 21. This 12-night, upscale voyage from Azamara Club Cruises makes a whopping nine stops throughout Ireland and Northern Ireland. Learn more.

Make your way from Tahiti to Sydney (with stops in Bora Bora, American Samoa, and New Zealand) on this epic 23-night cruise from Princess, which embarks from Pape'ete on February 8, 2022. Learn more.

Pay your respects at the historic beaches of Normandy, tour massive French châteaux, and hit the chic streets of Paris on this seven-night Seine River cruise from Teeming River Cruises, which sets sail on October 30, 2021. Learn more. 

Read more: How to Experience Paris Like a Local

More and more cruise lines are calling on ports in the Philippines, and this is one of the few itineraries dedicated solely to the beautiful island nation. Travel round-trip from Singapore aboard Royal Caribbean's Quantum of the Seas on March 2, 2021. Learn more.

Get the best of ancient and natural world wonders on this unique 15-night itinerary from Celebrity Cruises. Explore the Galapagos aboard the new Celebrity Flora; then, fly to Peru to tour Machu Picchu. Choose from several dates in 2021 and 2022. Learn more.

Read more: What to See and Do in Peru’s Sacred Valley
 

Embark on an eight-night safari adventure with CroisiEurope. Set sail aboard the 110-foot-long, 16-passenger African Dream on select dates between November and December 2021. Cap off your trip with an excursion to Victoria Falls. Learn more.

Read more: How to Go to Africa (and on a Safari) with a River Cruise

Viking Cruises is set to launch its new expedition ship in 2022. The vessel will sail the Great Lakes from late spring through early fall. Choose from two itineraries: Thunder Bay, Ontario to Milwaukee, Wisconsin; or Milwaukee to Toronto, Ontario. Learn more.

Read more: 10 Things to Know About Viking's New Expedition Ships