This five-star oasis, in the shadow of Mount Otemanu, was the fictitious "Eden" in the film Couples Retreat, starring Vince Vaughn, Jon Favreau, Kristen Bell, and Kristin Davis. Some creative license was taken (there are no separate couples and singles sections and, unfortunately, no loin-clothed yoga instructor), but the luxe overwater bungalows and sublime lagoon views are 100-percent real.

The iconic Las Vegas hotel-with its stately Forum Tower rooms and Garden of the Gods Pool Oasis-made a perfect home base for bachelor-party bacchanalia in The Hangover. Even without Bradley Cooper and his amnesiac cohorts, it's easy to go overboard between the 13 restaurants (with a fourteenth on its way), including haute Japanese eatery Nobu, and the customary bottomless drinks in the casino.

If you miss your flight connection and need a place to spend the night, take a cue from 10-Million-Mile flyer Ryan Bingham (aka George Clooney) and stay at the Hilton Miami Airport, featured in Up in the Air. Not your typical airport hotel, the property is surrounded by a 100-acre lake with a scenic jogging trail, and its modern suites have balconies overlooking a lagoon and the Miami skyline.

Unlike just-dumped Jason Segal in Forgetting Sarah Marshall, guests will be hard-pressed to run into an ex on this expansive, 800-acre property on Oahu's secluded North Shore. With lavish villas overlooking Kuilima Cove, and activities that range from luaus and massages to surf lessons and excursions, a week here will lift your mood whether you need it or not.

The best thing about the 2007 remake of The Heartbreak Kid (starring Ben Stiller) is the backdrop. At this stunning Los Cabos resort, you'll spend your days sunning by an infinity pool, dining cliff-side by candlelight, or relaxing on your private patio overlooking the ocean. Guests have access to personal concierge service and complimentary yoga daily as well.

At this romantic colonial mansion on Maryland's Eastern Shore, Owen Wilson and Vince Vaughn conned their way into the beds (and hearts) of bridesmaids Rachel McAdams and Isla Fisher in the 2005 film Wedding Crashers. The property exudes simple luxury-elegant modern furnishings, manicured lawns, and afternoon tea overlooking the Miles River, where colorful yachts are available for charter.

At this posh Paradise Island, Bahamas resort, Daniel Craig made his first appearance as James Bond in 2006's Casino Royale. Opened in 1962, and recently rebranded by the Four Seasons, the Ocean Club has 107 sophisticated, Caribbean-colonial rooms and suites, 35 acres of Versailles-inspired lawns, three swimming pools, a Jean-Georges restaurant, and access to an adjacent golf course.

The motel where Paul Giamatti and Thomas Haden Church embarked on a mid-life-crisis-cum-bachelor-getaway in Sideways has been revamped and renamed. Though not quite luxury, the stylish inn makes a refined, novel retreat to California's Santa Ynez Valley. It has a spa, lounge, and outdoor fire pit suited for sipping pinot with new friends, plus easy access to the area's wineries and hiking trails.

Fans of Lost In Translation can relive Bill Murray and Scarlett Johansson's dark-comedy boredom at this sleek Tokyo skyscraper by paying a visit to the panoramic New York Grill & Bar and serene lap pool. Occupying the top 14 floors of the 52-storey tower, the hotel is a calm oasis amid the chaotic Shinjuku business and entertainment district.