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San Franscisco's cutting-edge arts scene makes this city a must-see stop on any Cali roadtrip. Ideally located in between Union Square and the Financial District, the ultra-hip Hotel Des Arts offers one-of-a-kind  lodgings designed and painted by some of the world’s top emerging artists. The boutique hotel doubles as an art gallery with iconic art installations by Shepard Fairey and Tricia Choi and guestrooms covered with edgy graffiti-inspired designs. Summer rates start at just $99/night for rooms with a shared bath, or $149/night for a deluxe queen room with complimentary continental breakfast included. Plus, at these great rates, the savings really  add up on longer visits. Case in point: Book a 7-night stay and pay for only five of those nights.