Savona is a seaport in the northern Italian region of Liguria whose claim to fame has been its esteemed denizens. It was the home of Christopher Columbus and influential Popes Sixtus IV and Julius II, who have left their legacy on the coastal town (and who also commissioned the Sistine Chapel and the Michelangelo frescoes in Rome). The entrance into the harbor is dramatic and picturesque — a number of towers line the skyline, surrounded by hillside homes. Cruise ships dock right in the center of town where you can access the medieval quarter by foot.